Karolinska Institutet, MBB
Teknik Medicin Natur
More than 50% of the human genome codes for non-coding RNA. These RNAs are ubiquitous among all life forms and the mechanisms how non-coding RNAs regulate these functions are largely unknown.
Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function (“Visualizing transient low-populated structures of RNA” Nature 2012). When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions.
Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs or ribosomal RNAs. Master projects can be in the area of RNA biochemistry, structural biology of RNA, NMR development, simulations & programming or interdisciplinary.
Students have preferably a background in biochemistry, chemistry, molecular biology or physics with an interest in inter-disciplinary research. Applicants should be fluent in English (written and spoken), have innovative thinking and be eager to solve problems. Emphasis will be placed on personal suitability. Master projects can potentially be continued into PhD projects.